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Matt Karweck accepted the reins as the Colgate men's lacrosse head coach in July 2018.

During the 2024 season, Colgate posted an 8-7 record, clinching a berth into the Patriot League Tournament. The Raiders earned two wins over top-10 opponents, defeating No. 4 Penn State and No. 5 Army. Colgate had four All-Patriot League selections, and Matt LaCombe earned Patriot League Goalkeeper of the Year. Three players were also named All-American Honorable Mention. 

Karweck arrived after eight years as an assistant coach in the Division I ranks, including the previous six seasons at Notre Dame.
 
Karweck, who also played his collegiate lacrosse at Notre Dame, helped the Fighting Irish to their second Atlantic Coast Conference title in 2018 with a 17-7 championship-game triumph at Virginia. The Irish were matched only by Syracuse in ACC tournament success since Notre Dame joined the league, as both teams now have two championships in the five-year span.
 
The Irish reached three finals in five appearances.
 
During his six seasons back at Notre Dame, the Fighting Irish compiled a 64-30 record, earned six NCAA tournament bids, including a title-game appearance in 2014, captured the 2014 and 2018 Atlantic Coast Conference championships, and reclaimed the regular season ACC title in 2015 and 2016.
 
The Irish reached at least the NCAA quarterfinals in five of the six seasons Karweck served under head coach Kevin Corrigan.
 
Over his final six years with the Irish, the Notre Dame program produced 27 All-America honorees and 25 All-ACC selections. The Fighting Irish also had 10 players drafted into Major League Lacrosse. 

Karweck came to Notre Dame from Merrimack, where he spent one season as an assistant coach/offensive coordinator at the NCAA Division II school. The Warriors posted a 13-3 record in 2012 and reached the title game of the Northeast-10 Conference tournament. They also were ranked fifth nationally during the season and produced three All-Americans, including the player of the year.

Prior to his stint at Merrimack, Karweck was an assistant coach at the Detroit-Mercy for one season. He was the offensive coordinator for the Titans during the 2011 campaign and helped the second-year program improve by three wins from its first season of NCAA Division I play to its second. Detroit also earned its initial berth into the MAAC tournament and advanced to the title game. 

Karweck was the head coach of Indiana University's club lacrosse program from 2007-10. The squad competed in the Men's Collegiate Lacrosse Association (MCLA).
 
He led Indiana to 25 wins in three seasons and was named the 2009 Great Rivers Lacrosse Conference Coach of the Year. While at Indiana, he earned a Master of Science degree in kinesiology and owned and ran Overtime Lacrosse, a summer camp program. 

Karweck earned four letters (2003-06) and tallied 60 goals and 30 assists in 52 games during his playing career at Notre Dame. He received first team all-Great Western Lacrosse League honors as a senior after copping second-team accolades during his junior campaign. He graduated with a degree in psychology from Notre Dame's College of Arts and Letters. 

After graduating from Notre Dame, Karweck competed professionally in England for one season with the Sheffield Steelers in the English Lacrosse Premiership. The Steelers captured the 2006 Bath Eights Tournament Championship. While in England, he also served as a men's lacrosse coach at Sheffield University, and taught lacrosse in the surrounding area for the English Lacrosse Association. 

Karweck returned to the United States and played two seasons for the Chicago Machine in Major League Lacrosse. 
 
He and his wife, Dr. Andrea Karweck, a 2005 graduate of Notre Dame, have two sons, Kane and Maddox.